Article date: 1988/9/8
PubMed ID: 2851616
Journal name: The Journal of comparative neurology (ISSN: 0021-9967)
In order to visualize the relative abundance of each of three potentially inhibitory neurotransmitters in the nuclei of the brainstem auditory pathway, receptor sites for glycine, GABA-A, and muscarinic acetylcholine (ACh) have been localized in the cat's brainstem auditory system. Conventional autoradiographic receptor-binding procedures were used and the distributions of the receptors were inferred from the respective distributions of tritiated strychnine, muscimol, and quinuclidinyl benzilate (QNB) binding sites. The results show that glycine may be the major inhibitory neurotransmitter in the auditory system as it ascends to the midbrain in that relatively high levels of strychnine binding are present in every major nucleus of the system. In contrast, high levels of muscimol binding of high-affinity GABA-A receptors are confined mostly to the dorsal cochlear nucleus, the dorsal nucleus of the lateral lemniscus, and the central and cortical regions of the inferior colliculus, while high levels of QNB binding of muscarinic ACh receptors are seen only in the central and cortical regions of the inferior colliculus.
Author List: Glendenning K K, Baker B N
Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Receptors, GABA-A; Receptors, Glycine; Receptors, Muscarinic; Receptors, Neurotransmitter; Muscimol; Quinuclidinyl Benzilate; Strychnine; Glycine;
Mesh terms: Animals; Auditory Pathways/anatomy & histology; Brain/anatomy & histology; Brain Stem/anatomy & histology; Cats/anatomy & histology; Glycine/metabolism; Muscimol/metabolism; Quinuclidinyl Benzilate/metabolism; Receptors, GABA-A/metabolism; Receptors, Glycine; Receptors, Muscarinic/metabolism; Receptors, Neurotransmitter/metabolism; Strychnine/metabolism;