Paradoxical antagonism by bicuculline of the inhibition by baclofen of the electrically evoked release of [3H]GABA from rat cerebral cortex slices.

Article date: 1988/10/18

PubMed ID: 2853062

Journal name: European journal of pharmacology (ISSN: 0014-2999)


The presynaptic regulation of the electrically evoked release of [3H]GABA was studied in the rat cerebral cortex. Among the GABA receptor agonists tested (GABA, SL 75102, muscimol, THIP, isoguvacine, (+/-)-baclofen), only (+/-)-baclofen inhibited the stimulation-evoked release of [3H]GABA. This effect of baclofen was stereoselective in favor of the (-) enantiomer. The inhibition by (+/-)-baclofen of the electrically evoked release of [3H]GABA was antagonized by bicuculline and picrotoxin. Our results suggest that the release of [3H]GABA in vitro can be modulated by a receptor-mediated mechanism which is sensitive to baclofen, bicuculline and picrotoxin but not to GABA, muscimol or THIP.

This document is available from: http://directlinks.cc/files/muscimol/2853062.pdf

Author List: Maurin Y

Publication Types: Journal Article

Substances mentioned in the article: Receptors, GABA-A; gamma-Aminobutyric Acid; Baclofen; Bicuculline;

Mesh terms: Animals; Baclofen/antagonists & inhibitors; Bicuculline/pharmacology; Cerebral Cortex/drug effects; Electric Stimulation; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Stereoisomerism; gamma-Aminobutyric Acid/pharmacology;

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