Article date: 1993/7/1
PubMed ID: 2859146
Journal name: Neuroscience and behavioral physiology (ISSN: 0097-0549)
The functions of generalization and abstraction in an experimental model of Alzheimer's disease (the lesion of Meynert's nuclei in cats) were studied against the background of stimulation and inhibition of the cholinergic, GABAergic, and dopaminergic systems of the brain. It was demonstrated that the cholinergic system is a key system for the formation of the function of generalization, the dopaminergic system improves simple forms of learning, while the GABAergic system is actively involved in the establishment of complex types of associations.
Author List: Mukhin E I, Nabieva T N, Mukhina YuK
Publication Types: Journal Article
Substances mentioned in the article: Parasympatholytics; Ibotenic Acid; gamma-Aminobutyric Acid; Acetylcholine; Dopamine;
Mesh terms: Acetylcholine/physiology; Animals; Cats; Cognition/drug effects; Conditioning, Operant/drug effects; Dopamine/physiology; Female; Generalization, Stimulus/drug effects; Ibotenic Acid/toxicity; Male; Parasympatholytics/pharmacology; Problem Solving/drug effects; Substantia Innominata/anatomy & histology; gamma-Aminobutyric Acid/physiology;