2859146

The neuropharmacological restoration of cognitive functions of cats following a lesion to the basal nuclei of the forebrain (Meynert's nucleus).

Article date: 1993/7/1

PubMed ID: 2859146

Journal name: Neuroscience and behavioral physiology (ISSN: 0097-0549)

ABSTRACT

The functions of generalization and abstraction in an experimental model of Alzheimer's disease (the lesion of Meynert's nuclei in cats) were studied against the background of stimulation and inhibition of the cholinergic, GABAergic, and dopaminergic systems of the brain. It was demonstrated that the cholinergic system is a key system for the formation of the function of generalization, the dopaminergic system improves simple forms of learning, while the GABAergic system is actively involved in the establishment of complex types of associations.

Author List: Mukhin E I, Nabieva T N, Mukhina YuK

Publication Types: Journal Article

Substances mentioned in the article: Parasympatholytics; Ibotenic Acid; gamma-Aminobutyric Acid; Acetylcholine; Dopamine;

Mesh terms: Acetylcholine/physiology; Animals; Cats; Cognition/drug effects; Conditioning, Operant/drug effects; Dopamine/physiology; Female; Generalization, Stimulus/drug effects; Ibotenic Acid/toxicity; Male; Parasympatholytics/pharmacology; Problem Solving/drug effects; Substantia Innominata/anatomy & histology; gamma-Aminobutyric Acid/physiology;

Citations: - Effect of cholinesterase inhibitors on Morris water task behavior following lesions of the nucleus basalis magnocellularis.

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