2866236

Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus.

Article date: 1986/1/1

PubMed ID: 2866236

Journal name: Journal of neurochemistry (ISSN: 0022-3042)

ABSTRACT

Ibotenate, a rigid structural analogue of glutamate, markedly enhances the hydrolysis of membrane inositol phospholipids, as reflected by the stimulation of [3H]inositol monophosphate formation in rat hippocampal slices prelabeled with [3H]inositol and treated with Li+. Quisqualate, homocysteate, L-glutamate, and L-aspartate also induce a significant (albeit weaker) increase in [3H]inositol monophosphate formation, whereas N-methyl-D-aspartate, kainate, quinolinate, and N-acetylaspartylglutamate are inactive. The increase in [3H]inositol monophosphate formation elicited by the above-mentioned excitatory amino acids is potently and selectively antagonized by DL-2-amino-4-phosphonobutyric acid, a dicarboxylic amino acid receptor antagonist. These results suggest that, in the hippocampus, a class of dicarboxylic amino acid recognition sites is coupled with phospholipase C, the enzyme that catalyzes the hydrolysis of membrane inositol phospholipids.

Author List: Nicoletti F, Meek J L, Iadarola M J, Chuang D M, Roth B L, Costa E

Publication Types: Journal Article

Substances mentioned in the article: Glutamates; Oxadiazoles; Phosphatidylinositols; Receptors, Neurotransmitter; Ibotenic Acid; Aspartic Acid; Glutamic Acid; Quisqualic Acid; Calcium;

Mesh terms: Animals; Aspartic Acid/pharmacology; Calcium/physiology; Cerebral Cortex/drug effects; Corpus Striatum/drug effects; Dose-Response Relationship, Drug; Glutamates/pharmacology; Glutamic Acid; Hippocampus/drug effects; Ibotenic Acid/pharmacology; Male; Oxadiazoles/pharmacology; Phosphatidylinositols/metabolism; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter/drug effects; Spinal Cord/drug effects;

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