2867808

Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease.

Article date: 1985/12/30

PubMed ID: 2867808

Journal name: Brain research (ISSN: 0006-8993)

ABSTRACT

Huntington's disease is accompanied by severe neuronal death in the striatum, but despite this cell loss, there is a marked increase in the striatal concentration of somatostatin-like immunoreactivity (SLI). We attempted to examine the mechanism of this increase by using kainic or ibotenic acid to effect a unilateral lesion in the rat neostriatum. Graded doses of toxin cause a proportional decrease in the concentration of somatostatin-like immunoreactivity to a maximum of 50% of control, which is stable over an interval of 3 months. The increased somatostatin-like immunoreactivity in Huntington's disease is not mimicked by the excitotoxin lesions in rats. In addition we find that unilateral kainic acid lesions in the striatum reduce SLI in the contralateral striatum as well, although histologic evidence and assay of choline acetyltransferase activity indicate that damage is confined to the injected side. Immunocytochemistry demonstrates a loss of somatostatin-containing neurons on the lesioned side but no discernible loss in the contralateral striatum. The bilateral decrease in SLI following unilateral lesions suggests damage to a somatostatin projection to the contralateral striatum or a compensatory interaction between the two striatal nuclei.

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Author List: Beal M F, Marshall P E, Burd G D, Landis D M, Martin J B

Publication Types: Journal Article

Substances mentioned in the article: Immune Sera; Ibotenic Acid; Somatostatin; Enkephalin, Leucine; Kainic Acid;

Mesh terms: Animals; Brain/cytology; Corpus Striatum/drug effects; Disease Models, Animal; Enkephalin, Leucine/metabolism; Humans; Huntington Disease/metabolism; Ibotenic Acid/pharmacology; Immune Sera; Immunoassay; Kainic Acid/pharmacology; Male; Neurons/cytology; Radioimmunoassay; Rats; Rats, Inbred Strains; Somatostatin/metabolism; Tissue Distribution;

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