Article date: 1986/2/1
PubMed ID: 2868427
Journal name: Neurology (ISSN: 0028-3878)
We used in vitro receptor autoradiography to study four cases of olivopontocerebellar atrophy (OPCA) and three age- and postmortem delay-matched controls. In OPCA, benzodiazepine receptors were unchanged in cerebellar cortex but increased in the dentate nucleus, perhaps related to loss of Purkinje cell or brainstem afferents. Muscimol binding was reduced primarily in the granule cell layer. The density of muscarinic cholinergic receptors was reduced in molecular and granule cell layers, but appeared increased in the dentate.
Author List: Whitehouse P J, Muramoto O, Troncoso J C, Kanazawa I
Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Glutamates; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Neurotransmitter; Aspartic Acid; Glutamic Acid; gamma-Aminobutyric Acid;
Mesh terms: Aged; Aspartic Acid/metabolism; Atrophy; Autoradiography; Binding Sites; Cerebellum/pathology; Glutamates/metabolism; Glutamic Acid; Humans; In Vitro Techniques; Male; Middle Aged; Olivary Nucleus/pathology; Pons/pathology; Purkinje Cells/pathology; Receptors, Cholinergic/metabolism; Receptors, GABA-A/metabolism; Receptors, Muscarinic/metabolism; Receptors, Neurotransmitter/metabolism; gamma-Aminobutyric Acid/metabolism;