Article date: 1986/2/5
PubMed ID: 2868779
Journal name: Brain research (ISSN: 0006-8993)
The consequences of propylthiouracil-induced thyroid deficiency on pre- and postsynaptic biochemical markers in the corpus striatum and the visual cortex were investigated in adult rats. Hypothyroidism in adult rats significantly impaired (by 30%) striatal [3H]spiroperidol binding capacity. In the visual cortex, small but significant reductions in [3H]WB.4101 and in [3H]muscimol binding were evident, whereas glutamate decarboxylase activity was increased by 18% in the thyroid-deficient rats. Compatible with previous morphological evidence (Ruiz-Marcos et al.), the present observations may imply alterations in dendritic morphology of neurones in the striatum and cortex during long-term hypothyroidism in adult rats. However, the molecular changes observed suggest a differential sensitivity of transmitter-specific neurones in the central nervous system to thyroid hormone.
Author List: Kalaria R N, Prince A K
Publication Types: Journal Article
Substances mentioned in the article: Dioxanes; Receptors, Neurotransmitter; Muscimol; Spiperone; gamma-Aminobutyric Acid; Quinuclidinyl Benzilate; (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane; Tyrosine 3-Monooxygenase; Choline O-Acetyltransferase; Glutamate Decarboxylase;
Mesh terms: Animals; Choline O-Acetyltransferase/metabolism; Corpus Striatum/metabolism; Dioxanes/metabolism; Glutamate Decarboxylase/metabolism; Hypothyroidism/metabolism; Muscimol/metabolism; Quinuclidinyl Benzilate/metabolism; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter/metabolism; Spiperone/metabolism; Tyrosine 3-Monooxygenase/metabolism; Visual Cortex/metabolism; gamma-Aminobutyric Acid/metabolism;