Control of rat gastric somatostatin release by gamma-aminobutyric acid (GABA).

Article date: 1986/2/1

PubMed ID: 2870970

Journal name: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (ISSN: 0018-5043)


The influence of gamma-aminobutyric acid (GABA) on gastric somatostatin and gastrin release was studied using an isolated perfused rat stomach preparation. GABA dose-dependently inhibited somatostatin release (maximal inhibition of 44% at 10(-5)M GABA), whereas gastrin secretion was not affected. The GABA agonist muscimol led to a decrease in somatostatin release of similar magnitude. The GABA-induced changes were partially reversed by 10(-5)M atropine. Gastrin secretion was not influenced by either protocol. It is concluded that GABA as a putative neurotransmitter in the enteric nervous system is inhibitory to rat gastric somatostatin release in vitro via cholinergic pathways.

This document is available from: http://directlinks.cc/files/muscimol/2870970.pdf

Author List: Koop H, Arnold R

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Gastrins; Muscimol; Somatostatin; gamma-Aminobutyric Acid; Atropine;

Mesh terms: Animals; Atropine/pharmacology; Gastric Mucosa/secretion; Gastrins/secretion; In Vitro Techniques; Male; Muscimol/pharmacology; Radioimmunoassay; Rats; Rats, Inbred Strains; Somatostatin/secretion; Time Factors; gamma-Aminobutyric Acid/pharmacology;

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