Article date: 1987/8/11
PubMed ID: 2888515
Journal name: Brain research (ISSN: 0006-8993)
Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons.
Author List: Mufson E J, Kehr A D, Wainer B H, Mesulam M M
Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Oxazoles; Ibotenic Acid; Somatostatin; Choline O-Acetyltransferase; Acetylcholinesterase;
Mesh terms: Acetylcholinesterase/metabolism; Animals; Basal Ganglia/cytology; Cell Count; Cerebral Cortex/cytology; Choline O-Acetyltransferase/metabolism; Cholinergic Fibers/drug effects; Ibotenic Acid/toxicity; Immunoenzyme Techniques; Male; Neurons/classification; Oxazoles/toxicity; Rats; Rats, Inbred Strains; Somatostatin/metabolism;