Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons.

Article date: 1987/8/11

PubMed ID: 2888515

Journal name: Brain research (ISSN: 0006-8993)


Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons.

Author List: Mufson E J, Kehr A D, Wainer B H, Mesulam M M

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Oxazoles; Ibotenic Acid; Somatostatin; Choline O-Acetyltransferase; Acetylcholinesterase;

Mesh terms: Acetylcholinesterase/metabolism; Animals; Basal Ganglia/cytology; Cell Count; Cerebral Cortex/cytology; Choline O-Acetyltransferase/metabolism; Cholinergic Fibers/drug effects; Ibotenic Acid/toxicity; Immunoenzyme Techniques; Male; Neurons/classification; Oxazoles/toxicity; Rats; Rats, Inbred Strains; Somatostatin/metabolism;

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