2889171

AMPA is a powerful neurotoxin in the chicken retina.

Article date: 1987/8/31

PubMed ID: 2889171

Journal name: Neuroscience letters (ISSN: 0304-3940)

ABSTRACT

Intravitreal (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazoleacetic acid (AMPA) is a powerful excitotoxin on the chicken retina. Doses of 10 nmol/eye produce half-maximum destruction of cholinergic amacrine cells, making AMPA equipotent with kainic acid. The effects of AMPA can be distinguished from those of kainic acid morphologically, and from those of N-methyl-D-aspartic acid by the failure of 2-amino-5-phosphonopentanoic acid (2-AP5) to block those of AMPA. Both morphologically, and in response to 2-AP5, the effects of AMPA and quisqualic acid are indistinguishable, but AMPA is much more potent than quisqualic acid, presumably due to the uptake and inactivation of quisqualic acid.

Author List: Morgan I G

Publication Types: Journal Article

Substances mentioned in the article: Oxadiazoles; Oxazoles; Ibotenic Acid; Aspartic Acid; N-Methylaspartate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Quisqualic Acid; Choline O-Acetyltransferase; Kainic Acid;

Mesh terms: Animals; Aspartic Acid/analogs & derivatives; Chickens; Choline O-Acetyltransferase/metabolism; Dose-Response Relationship, Drug; Ibotenic Acid/analogs & derivatives; Injections; Kainic Acid/pharmacology; N-Methylaspartate; Nerve Degeneration/drug effects; Oxadiazoles/pharmacology; Oxazoles/toxicity; Quisqualic Acid; Retina/drug effects; Retinal Ganglion Cells/drug effects; Vitreous Body; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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