Article date: 1988/3/1
PubMed ID: 2898033
Journal name: Japanese journal of pharmacology (ISSN: 0021-5198)
The propensity of SM-3997 to displace 3H-ligands was tested in vitro in a number of receptor-binding assays. SM-3997 possessed a high affinity towards 5-HT1A receptors, low affinity towards dopamine (D2) and 5-HT2 receptors, and no affinity towards benzodiazepine (BZ), GABA, 5-HT1B and adrenergic receptors. Moreover, SM-3997 facilitated neither 3H-flunitrazepam binding nor 3H-muscimol binding. These results suggest that the action of SM-3997 may be mediated via central 5-HT1A receptors but not the BZ-GABA receptor complex.
Author List: Shimizu H, Karai N, Hirose A, Tatsuno T, Tanaka H, Kumasaka Y, Nakamura M
Publication Types: Journal Article
Substances mentioned in the article: Anti-Anxiety Agents; Isoindoles; Piperazines; Pyrimidines; Receptors, Adrenergic, alpha; Receptors, Serotonin; tandospirone;
Mesh terms: Animals; Anti-Anxiety Agents/pharmacology; Binding, Competitive; Brain/drug effects; In Vitro Techniques; Isoindoles; Male; Piperazines/metabolism; Pyrimidines/metabolism; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha/drug effects; Receptors, Serotonin/drug effects;