2898899

Interactions of ACTH4-10 and ACTH1-24 with L-[3H]glutamate binding sites and GABA/benzodiazepine/picrotoxin receptor complexes in vitro.

Article date: 1988/1/1

PubMed ID: 2898899

Journal name: Brain & development (ISSN: 0387-7604)

ABSTRACT

The effects of ACTH4-10 and ACTH1-24 on L-[3H]glutamate (Glu) binding sites and GABA/benzodiazepine/picrotoxin receptor complexes in vitro were investigated. ACTH4-10 and ACTH1-24 inhibited [3H] Glu and [3H] muscimol binding concentration-dependently, while [3H] flunitrazepam (FNP) and [35S] t-butylbicyclophosphorothionate (TBPS) binding were not affected. These ACTH fragments also inhibited GABA-stimulated [3H] FNP binding. These results suggest that ACTH and its fragments may act as anticonvulsants by antagonizing glutamate binding, their interaction with GABA-A sites may relate to the other central nervous effects of ACTH than the anticonvulsant activity.

This document is available from: http://directlinks.cc/files/muscimol/2898899.pdf

Author List: Ito M, Yu O, Chiu T H

Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Glutamates; Peptide Fragments; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; picrotoxinin receptor; Muscimol; Glutamic Acid; Flunitrazepam; tert-butylbicyclophosphorothionate; Adrenocorticotropic Hormone; ACTH (4-10);

Mesh terms: Adrenocorticotropic Hormone/metabolism; Animals; Binding Sites; Bridged Bicyclo Compounds/metabolism; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex/metabolism; Flunitrazepam/metabolism; Glutamates/metabolism; Glutamic Acid; Male; Muscimol/metabolism; Peptide Fragments/metabolism; Rats; Rats, Inbred Strains; Receptors, GABA-A/metabolism; Receptors, Glutamate; Receptors, Neurotransmitter/metabolism;

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