Chaotropic ions affect the conformation of quisqualate receptors in rat cortical membranes.

Article date: 1988/8/1

PubMed ID: 2899131

Journal name: Journal of neurochemistry (ISSN: 0022-3042)


Binding of [3H](R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ([3H]AMPA) to quisqualate receptors in the presence of SCN- ions produced curvilinear Scatchard plots. Kinetic investigations of [3H]AMPA binding showed that the curvilinearity cannot be explained by assuming binding to two separate binding sites or by considering it due to cooperative interaction. A more likely explanation is that the quisqualate receptors exist in two states, one with high and one with low affinity for [3H]AMPA. Chaotropic ions change the relaxation constant between the two states.

This document is available from: http://directlinks.cc/files/muscimol/2899131.pdf

Author List: Honoré T, Drejer J

Publication Types: Journal Article

Substances mentioned in the article: Cyanates; Cyanides; Receptors, AMPA; Receptors, Drug; Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

Mesh terms: Animals; Cerebral Cortex/drug effects; Cyanates/pharmacology; Cyanides/pharmacology; Ibotenic Acid/analogs & derivatives; Kinetics; Membranes/drug effects; Protein Conformation/drug effects; Rats; Receptors, AMPA; Receptors, Drug/drug effects; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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