Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.

Article date: 1988/8/5

PubMed ID: 2899909

Journal name: Science (New York, N.Y.) (ISSN: 0036-8075)


The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the “non-NMDA” glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.

This document is available from: http://directlinks.cc/files/muscimol/2899909.pdf

Author List: Honoré T, Davies S N, Drejer J, Fletcher E J, Jacobsen P, Lodge D, Nielsen F E

Publication Types: Comparative Study; Journal Article

Substances mentioned in the article: Piperazines; Quinoxalines; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Ibotenic Acid; Aspartic Acid; FG 9041; N-Methylaspartate; Ketamine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; Kainic Acid;

Mesh terms: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials/drug effects; Animals; Aspartic Acid/analogs & derivatives; Binding, Competitive; Cell Membrane/metabolism; Cerebral Cortex/metabolism; Ibotenic Acid/analogs & derivatives; Kainic Acid/metabolism; Ketamine/pharmacology; N-Methylaspartate; Neurons/physiology; Piperazines/metabolism; Quinoxalines/pharmacology; Rats; Receptors, AMPA; Receptors, Drug/drug effects; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter/drug effects; Spinal Cord/physiology; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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