Article date: 1988/6/1
PubMed ID: 2902646
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
alpha-Amino-3-hydroxy-5- methylisoxazole-4-propionate (AMPA) is an excitatory amino acid which on the basis of electrophysiological and binding studies appears to act as a quisqualic acid receptor agonist. AMPA and other excitatory amino acids, such as quisqualic acid, kainic acid, and N-methyl-D-aspartic acid, as well as picrotoxin, an inhibitor of endogenous GABA, produce a marked stimulation of locomotor activity after bilateral injection into the nucleus accumbens. The intraacumbens injection of gamma-D-glutamylaminomethylsulphonate (GAMS) was found to inhibit the hypermotility responses produced by AMPA and quisqualic acid at doses that were unable to inhibit the hypermotility responses produced by kainic acid, N-methyl-D-aspartic acid, and picrotoxin. These results suggest that GAMS is able to selectively inhibit quisqualic acid receptors in the nucleus accumbens. The intraacumbens injection of D-alpha-aminoadipic acid at a dose that significantly inhibited N-methyl-D-aspartic acid-stimulated locomotor activity did not produce a significant inhibition of AMPA-stimulated locomotor activity, suggesting that AMPA is not acting at N-methyl-D-aspartic acid receptors. Thus, these results suggest that the activation of quisqualic acid receptors in the nucleus accumbens produces a hypermotility response.
Author List: Shreve P E, Uretsky N J
Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Glutamates; Oxadiazoles; Oxazoles; Receptors, AMPA; Receptors, Drug; Glutamine; 2-Aminoadipic Acid; Ibotenic Acid; Aspartic Acid; N-Methylaspartate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Quisqualic Acid; gamma-glutamylaminomethylsulfonic acid; Kainic Acid;
Mesh terms: 2-Aminoadipic Acid/pharmacology; Animals; Aspartic Acid/analogs & derivatives; Glutamates/pharmacology; Glutamine/analogs & derivatives; Ibotenic Acid/administration & dosage; Injections; Kainic Acid/pharmacology; Locomotion/drug effects; Male; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles/pharmacology; Oxazoles/pharmacology; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug/physiology; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;