Kynurenic acid and AP5 distinguish between NMDA receptor agonists.

Article date: 1988/12/1

PubMed ID: 2904376

Journal name: Experimental neurology (ISSN: 0014-4886)


Quantitative analysis of responses to amino acids in mouse cortical slices has indicated that the antagonists kynurenate and 2-amino-5-phosphonopentanoic acid distinguish between ibotenate and both N-methyl-D-aspartate (NMDA) and quinolinate. This result is consistent with the existence of NMDA-receptor subtypes.

Author List: Williams T L, Stone T W, Burton N R, Smith D A

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Ibotenic Acid; Aspartic Acid; N-Methylaspartate; 2-Amino-5-phosphonovalerate; Quinolinic Acid; Kynurenic Acid; Valine;

Mesh terms: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid/analogs & derivatives; Dose-Response Relationship, Drug; Ibotenic Acid/antagonists & inhibitors; Kynurenic Acid/metabolism; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter/drug effects; Valine/analogs & derivatives;

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