2905924

Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation.

Article date: 1988/9/1

PubMed ID: 2905924

Journal name: Brain research (ISSN: 0006-8993)

ABSTRACT

Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-D-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.

Author List: Palmer E, Monaghan D T, Cotman C W

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Chlorides; Glutamates; Oxadiazoles; Phosphatidylinositols; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Ibotenic Acid; Aspartic Acid; Tetrodotoxin; N-Methylaspartate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Quisqualic Acid; Lithium; Lithium Chloride; Kainic Acid;

Mesh terms: Animals; Aspartic Acid/analogs & derivatives; Chlorides/pharmacology; Glutamates/metabolism; Hippocampus/drug effects; Ibotenic Acid/analogs & derivatives; In Vitro Techniques; Kainic Acid/pharmacology; Lithium/pharmacology; Lithium Chloride; N-Methylaspartate; Oxadiazoles/pharmacology; Phosphatidylinositols/metabolism; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter/drug effects; Tetrodotoxin/pharmacology; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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