Presynaptic and postsynaptic D1 dopamine receptors in the nigrostriatal system of the rat brain: a quantitative autoradiographic study using the selective D1 antagonist [3H]SCH 23390.

Article date: 1987/4/7

PubMed ID: 2954613

Journal name: Brain research (ISSN: 0006-8993)


Ibotenic acid lesions of the caudate-putamen in rat brain resulted in dramatic reductions in [3H]SCH 23390 binding in both the ipsilateral caudate-putamen and substantia nigra reticulata as assessed by quantitative autoradiography. Nigral ibotenic acid and 6-hydroxydopamine lesions did not significantly alter the binding in either structure. This indicates that D1 receptors in the caudate-putamen are postsynaptic on striatal neurons, while those in the substantia nigra reticulata are presynaptic on nerve terminals originating in the caudate-putamen.

Author List: Filloux F M, Wamsley J K, Dawson T M

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Benzazepines; Hydroxydopamines; Receptors, Dopamine; Receptors, Dopamine D1; Ibotenic Acid; Oxidopamine;

Mesh terms: Animals; Autoradiography; Benzazepines; Caudate Nucleus/metabolism; Hydroxydopamines; Ibotenic Acid; Male; Oxidopamine; Putamen/metabolism; Rats; Rats, Inbred Strains; Receptors, Dopamine/metabolism; Receptors, Dopamine D1; Substantia Nigra/metabolism;

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