Article date: 1985/1/1
PubMed ID: 2981298
Journal name: The Journal of neuroscience : the official journal of the Society for Neuroscience (ISSN: 0270-6474)
The synaptic receptors of ON bipolar neurons are selectively activated by 2-amino-4-phosphonobutyrate, a glutamate analogue. This agent uniquely distinguishes these receptors from other types of excitatory amino acid receptors found in the retina. Various glutamate and aspartate analogues were used to assess the structure-activity characteristics of this receptor. The results suggest that it represents one class of glutamate receptor which can be distinguished by its preferential activation by acidic amino acid analogues that match the extended conformation of glutamate.
Author List: Slaughter M M, Miller R F
Publication Types: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Aminobutyrates; Glutamates; Receptors, Glutamate; Receptors, Neurotransmitter; Cycloleucine; 1-amino-1,3-dicarboxycyclopentane; Phosphoserine; Ibotenic Acid; 2-amino-4-phosphonobutyric acid;
Mesh terms: Aminobutyrates/pharmacology; Animals; Cycloleucine/analogs & derivatives; Electrophysiology; Glutamates/pharmacology; Ibotenic Acid/pharmacology; Light; Molecular Conformation; Necturus maculosus; Neurons/metabolism; Phosphoserine/pharmacology; Photoreceptor Cells/physiology; Receptors, Glutamate; Receptors, Neurotransmitter/drug effects; Retina/metabolism; Structure-Activity Relationship;