Article date: 1985/3/15
PubMed ID: 2986057
Journal name: Neuroscience letters (ISSN: 0304-3940)
Experiments were carried out to investigate the participation of the striatonigral and nigrocollicular GABAergic pathways in the expression of haloperidol-induced tonic electromyographic (EMG) activity of the gastrocnemius-soleus muscle in awake rats. It was shown that bilateral injections of haloperidol (500 ng/0.5 microliter) into the rostral part of the neostriatum induced a tonic EMG activity which could be significantly reduced by a second bilateral injection of muscimol (25 ng/0.5 microliter) into the substantia nigra pars reticulata (SNR) or of bicuculline (50 ng/0.5 microliter) into the intermediate or deep layers of the colliculus superior (CS). These results suggest that the striatonigral and nigrocollicular GABAergic pathways play a critical role in the transmission of haloperidol-induced tonic EMG activity.
Author List: Ellenbroek B, Schwarz M, Sontag K H, Cools A
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: gamma-Aminobutyric Acid; Haloperidol;
Mesh terms: Animals; Brain Mapping; Corpus Striatum/drug effects; Electromyography; Haloperidol/pharmacology; Male; Muscle Rigidity/chemically induced; Muscles/physiopathology; Neural Pathways/physiopathology; Rats; Rats, Inbred Strains; Substantia Nigra/physiopathology; Superior Colliculi/physiopathology; Synaptic Transmission; gamma-Aminobutyric Acid/physiology;