2986057

The importance of the striato-nigro-collicular pathway in the expression of haloperidol-induced tonic electromyographic activity.

Article date: 1985/3/15

PubMed ID: 2986057

Journal name: Neuroscience letters (ISSN: 0304-3940)

ABSTRACT

Experiments were carried out to investigate the participation of the striatonigral and nigrocollicular GABAergic pathways in the expression of haloperidol-induced tonic electromyographic (EMG) activity of the gastrocnemius-soleus muscle in awake rats. It was shown that bilateral injections of haloperidol (500 ng/0.5 microliter) into the rostral part of the neostriatum induced a tonic EMG activity which could be significantly reduced by a second bilateral injection of muscimol (25 ng/0.5 microliter) into the substantia nigra pars reticulata (SNR) or of bicuculline (50 ng/0.5 microliter) into the intermediate or deep layers of the colliculus superior (CS). These results suggest that the striatonigral and nigrocollicular GABAergic pathways play a critical role in the transmission of haloperidol-induced tonic EMG activity.

This document is available from: http://directlinks.cc/files/muscimol/2986057.pdf

Author List: Ellenbroek B, Schwarz M, Sontag K H, Cools A

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: gamma-Aminobutyric Acid; Haloperidol;

Mesh terms: Animals; Brain Mapping; Corpus Striatum/drug effects; Electromyography; Haloperidol/pharmacology; Male; Muscle Rigidity/chemically induced; Muscles/physiopathology; Neural Pathways/physiopathology; Rats; Rats, Inbred Strains; Substantia Nigra/physiopathology; Superior Colliculi/physiopathology; Synaptic Transmission; gamma-Aminobutyric Acid/physiology;

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