2987029

[Tetrodotoxin competition with muscimol for the gamma-aminobutyric acid receptor].

Article date: 1985/3/1

PubMed ID: 2987029

Journal name: Farmakologiia i toksikologiia (ISSN: 0014-8318)

ABSTRACT

It has been shown that tetrodotoxin inhibits GABA-receptor binding of muscimol with solubilized membranes of the rat brain in a competitive manner, with the inhibition constant amounting to about 3 nM. Muscimol has been also demonstrated to competitively inhibit 3H-tetrodotoxin binding with the same drug.

Author List: Kuznetsov V I, Tonkikh A K, Karanova M V, Sadykov A A

Publication Types: English Abstract; Journal Article

Substances mentioned in the article: Oxazoles; Receptors, GABA-A; Tritium; Muscimol; Tetrodotoxin; gamma-Aminobutyric Acid;

Mesh terms: Animals; Binding, Competitive/drug effects; Brain/metabolism; Muscimol/antagonists & inhibitors; Oxazoles/metabolism; Rats; Receptors, GABA-A/metabolism; Solubility; Tetrodotoxin/antagonists & inhibitors; Tritium; gamma-Aminobutyric Acid/metabolism;

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