Article date: 1985/7/1
PubMed ID: 2988991
Journal name: Experimental neurology (ISSN: 0014-4886)
The chronological effect of intracerebral injection of GABAergic drugs, either muscimol or gabaculine, into the substantia innominata, was examined in amygdala-kindled cats. Results obtained indicate: that the substantia innominata may play a significant role in ictal linkage between a nonmotor system such as the amygdala and the motor mechanism responsible for amygdala-kindled convulsion, and that the GABA terminals in the substantia innominata exert a suppressive action toward convulsive seizure generalization of amygdala origin.
Author List: Morita K, Okamoto M, Seki K, Wada J A
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Cyclohexanecarboxylic Acids; Muscimol; gabaculine; gamma-Aminobutyric Acid;
Mesh terms: Amygdala/physiology; Animals; Basal Ganglia/physiopathology; Cats; Cyclohexanecarboxylic Acids/therapeutic use; Injections; Kindling, Neurologic; Muscimol/therapeutic use; Seizures/drug therapy; Substantia Innominata/physiopathology; Synaptic Transmission; gamma-Aminobutyric Acid/physiology;