2988991

Suppression of amygdala-kindled seizure in cats by enhanced GABAergic transmission in the substantia innominata.

Article date: 1985/7/1

PubMed ID: 2988991

Journal name: Experimental neurology (ISSN: 0014-4886)

ABSTRACT

The chronological effect of intracerebral injection of GABAergic drugs, either muscimol or gabaculine, into the substantia innominata, was examined in amygdala-kindled cats. Results obtained indicate: that the substantia innominata may play a significant role in ictal linkage between a nonmotor system such as the amygdala and the motor mechanism responsible for amygdala-kindled convulsion, and that the GABA terminals in the substantia innominata exert a suppressive action toward convulsive seizure generalization of amygdala origin.

This document is available from: http://directlinks.cc/files/muscimol/2988991.pdf

Author List: Morita K, Okamoto M, Seki K, Wada J A

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Cyclohexanecarboxylic Acids; Muscimol; gabaculine; gamma-Aminobutyric Acid;

Mesh terms: Amygdala/physiology; Animals; Basal Ganglia/physiopathology; Cats; Cyclohexanecarboxylic Acids/therapeutic use; Injections; Kindling, Neurologic; Muscimol/therapeutic use; Seizures/drug therapy; Substantia Innominata/physiopathology; Synaptic Transmission; gamma-Aminobutyric Acid/physiology;

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