Article date: 1985/10/1
PubMed ID: 2999835
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
The effects of the benzodiazepine receptor agonists, antagonists and inverse agonists on the in vitro binding of several ligands which label different recognition sites of the GABA benzodiazepine receptor complex are summarized. Also, results with a novel biochemical in vitro functional model of the GABA benzodiazepine receptor complex are presented. They are compatible with the concept that drugs which act on benzodiazepine receptors can lead to a bidirectional modulation of the gain of GABAergic neurotransmission.
Author List: Karobath M, Supavilai P
Publication Types: Journal Article; Review
Substances mentioned in the article: Barbiturates; Receptors, GABA-A; Muscimol; gamma-Aminobutyric Acid;
Mesh terms: Animals; Barbiturates/pharmacology; Drug Interactions; Models, Biological; Muscimol/metabolism; Rats; Receptors, GABA-A/drug effects; gamma-Aminobutyric Acid/pharmacology;