GABA antagonists increase the release of [3H]acetylcholine from the chick retina.

Article date: 1986/1/1

PubMed ID: 3006434

Journal name: Acta physiologica Scandinavica (ISSN: 0001-6772)


The release of [3H]acetylcholine from the chick retina was studied. A 5 mM increase in K+-concentration caused an increased release, which was Ca2+-dependent. The effect of 5 mM K+ was neither potentiated by bicuculline nor inhibited by isoguvacine or muscimol. This indicates that the K+-induced release is not controlled by GABA. However, bicuculline and picrotoxin increased the spontaneous efflux of radioactivity, whereas GABA had no significant effect. The results suggest that cholinergic neurons are tonically inhibited by a continuous release of endogenous GABA. Neither glycine or strychnine, nor dopamine or haloperidol had any effect on the spontaneous release.

This document is available from: http://directlinks.cc/files/muscimol/3006434.pdf

Author List: Agardh E

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: GABA Antagonists; Receptors, GABA-A; Picrotoxin; gamma-Aminobutyric Acid; Strychnine; Haloperidol; Choline; Acetylcholine; Potassium; Glycine; Dopamine; Bicuculline;

Mesh terms: Acetylcholine/metabolism; Animals; Bicuculline/pharmacology; Chickens; Choline/pharmacology; Dopamine/pharmacology; GABA Antagonists; Glycine/pharmacology; Haloperidol/pharmacology; In Vitro Techniques; Photic Stimulation; Picrotoxin/pharmacology; Potassium/pharmacology; Receptors, GABA-A/drug effects; Retina/drug effects; Strychnine/pharmacology; gamma-Aminobutyric Acid/pharmacology;

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