Article date: 1986/2/28
PubMed ID: 3008043
Journal name: Neuroscience letters (ISSN: 0304-3940)
Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats. Focal injection of the selective N-methyl-D-aspartate receptor antagonist, (+/-)-2-amino-7-phosphonoheptanoic acid (2-APH, 5-20 pmol), bilaterally into the entopeduncular nucleus (EP) prior to pilocarine blocks these seizures. Muscimol (50 pmol), a potent gamma-aminobutyric acid receptor agonist, injected bilaterally into EP produces a similar protection against pilocarpine-induced seizures. Thus by blocking excitatory neurotransmission or facilitating inhibition within the EP, the severity of limbic seizures can be reduced.
Author List: Patel S, Millan M H, Mello L M, Meldrum B S
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Amino Acids; Anticonvulsants; Pilocarpine; Muscimol; 2-Amino-5-phosphonovalerate; 2-amino-7-phosphonoheptanoic acid;
Mesh terms: 2-Amino-5-phosphonovalerate/analogs & derivatives; Amino Acids/therapeutic use; Animals; Anticonvulsants/therapeutic use; Basal Ganglia/drug effects; Male; Muscimol/therapeutic use; Neural Inhibition/drug effects; Pilocarpine/antagonists & inhibitors; Rats; Rats, Inbred Strains; Seizures/chemically induced; Synaptic Transmission/drug effects;