[Nonuniform effect of prolonged haloperidol administration on the GABA(A) and benzodiazepine receptors in different parts of the brain].

Article date: 1986/4/1

PubMed ID: 3008878

Journal name: Biulleten' eksperimental'noi biologii i meditsiny (ISSN: 0365-9615)


The experiments on male mice and rats have revealed reversed behavioral effects of muscimol and Ro 15-1788 after 15 days of haloperidol (0.25 mg/kg, twice daily) treatment. Muscimol (0.75 mg/kg), which depressed motor activity in saline-pretreated mice, stimulated it after discontinuation of long-term haloperidol administration. Ro 15-1788 stimulating effect in saline-pretreated rats gave way to sedative effect following haloperidol withdrawal. Simultaneously, the number of 3H-muscimol and 3H-flunitrazepam binding sites was decreased in forebrain, but increased in hindbrain. It was suggested that GABAA and benzodiazepine receptors in forebrain and hindbrain play opposite (inhibiting and stimulating, respectively) functional roles in the regulation of behaviour.

Author List: Vasar E E, Nurk A M, Maĭmets M O, Soosaar A Kh, Allikmets L Kh

Publication Types: Comparative Study; English Abstract; Journal Article

Substances mentioned in the article: Benzodiazepinones; Receptors, GABA-A; Muscimol; Flumazenil; Haloperidol;

Mesh terms: Animals; Behavior, Animal/drug effects; Benzodiazepinones/pharmacology; Brain/drug effects; Flumazenil; Haloperidol/pharmacology; Male; Mice; Muscimol/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Time Factors;

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