Nipecotic acid, an uptake blocker, prevents fading of the gamma-aminobutyric acid effect.

Article date: 1986/2/26

PubMed ID: 3008910

Journal name: Brain research (ISSN: 0006-8993)


In rats under urethane, iontophoretic applications of GABA (30-60 nA) in the str. pyramidale of CA1, showed a rapidly fading inhibitory effect. By contrast, GABA had a well-maintained inhibitory effect in str. radiatum. During iontophoresis of nipecotic acid (30-85 nA) identical applications of GABA in str. pyramidale caused a more prominent depression without fading, which suggests that removal of GABA, by uptake, can at least in part account for 'fading'. Nipecotic acid also prolonged the paired-pulse inhibition, presumably by prolonging the duration of inhibitory postsynaptic potentials.

This document is available from: http://directlinks.cc/files/muscimol/3008910.pdf

Author List: Dalkara T

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Nipecotic Acids; Receptors, GABA-A; nipecotic acid; Muscimol; gamma-Aminobutyric Acid; Proline; homoproline;

Mesh terms: Animals; Drug Synergism; Hippocampus/drug effects; Male; Muscimol/administration & dosage; Nipecotic Acids/administration & dosage; Proline/analogs & derivatives; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; gamma-Aminobutyric Acid/administration & dosage;

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