Localization of GABAA and GABAB receptor subtypes on serotonergic neurons.

Article date: 1986/4/23

PubMed ID: 3008948

Journal name: Brain research (ISSN: 0006-8993)


The effect of selective destruction of serotonin (5-HT)-containing neurons with 5,7-dihydroxytryptamine (5,7-DHT) on [3H] muscimol and (-)-[3H]baclofen binding was investigated in various rat brain regions. Ten days after intracerebroventricular 5,7-DHT, serotonin levels and [3H]imipramine binding were markedly decreased. 5,7-DHT reduced [3H]muscimol binding only in the mesencephalon, and (-)-[3H]baclofen binding was unmodified in all the areas considered. These results suggest that except in the mesencephalon GABA receptors may not be localized on serotonergic nerve terminals.

This document is available from: http://directlinks.cc/files/muscimol/3008948.pdf

Author List: Mennini T, Gobbi M, Romandini S

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, GABA-A; Muscimol; 5,7-Dihydroxytryptamine; Serotonin; Baclofen; Imipramine;

Mesh terms: 5,7-Dihydroxytryptamine/administration & dosage; Animals; Baclofen/metabolism; Brain/metabolism; Imipramine/metabolism; Male; Muscimol/metabolism; Neurons/classification; Rats; Rats, Inbred Strains; Receptors, GABA-A/analysis; Serotonin/physiology; Synaptosomes/metabolism;

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