Article date: 1986/4/23
PubMed ID: 3008948
Journal name: Brain research (ISSN: 0006-8993)
The effect of selective destruction of serotonin (5-HT)-containing neurons with 5,7-dihydroxytryptamine (5,7-DHT) on [3H] muscimol and (-)-[3H]baclofen binding was investigated in various rat brain regions. Ten days after intracerebroventricular 5,7-DHT, serotonin levels and [3H]imipramine binding were markedly decreased. 5,7-DHT reduced [3H]muscimol binding only in the mesencephalon, and (-)-[3H]baclofen binding was unmodified in all the areas considered. These results suggest that except in the mesencephalon GABA receptors may not be localized on serotonergic nerve terminals.
Author List: Mennini T, Gobbi M, Romandini S
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Receptors, GABA-A; Muscimol; 5,7-Dihydroxytryptamine; Serotonin; Baclofen; Imipramine;
Mesh terms: 5,7-Dihydroxytryptamine/administration & dosage; Animals; Baclofen/metabolism; Brain/metabolism; Imipramine/metabolism; Male; Muscimol/metabolism; Neurons/classification; Rats; Rats, Inbred Strains; Receptors, GABA-A/analysis; Serotonin/physiology; Synaptosomes/metabolism;