Article date: 1986/3/1
PubMed ID: 3010337
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
Intra olfactory bulb administration of three classes of GABA-mimetics (GABAa agonists, inhibitors of reuptake, inhibitors of GABA degradation) clearly inhibit mouse-killing behavior, without sedation. A linear correlation is observed between GABA levels increase in the olfactory bulbs and muricidal inhibition following local injection of valproic acid and gamma-vinyl GABA, two GABA-T inhibitors; the differences observed between these two compounds may be due to the differences in their mechanism of action on GABA-T activity and to the different pool of GABA on which they act. No diffusion to extra bulbar sites were observed after local administration of gamma-vinyl GABA. This evidence suggests an inhibitory role of GABA from olfactory bulbs in the modulation of mouse-killing behavior.
Author List: Molina V, Ciesielski L, Gobaille S, Mandel P
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Aminocaproates; Isonicotinic Acids; Isoxazoles; Nipecotic Acids; nipecotic acid; Muscimol; gamma-Aminobutyric Acid; Valproic Acid; Proline; homoproline; Vigabatrin; gaboxadol; isoguvacine;
Mesh terms: Aggression/drug effects; Aminocaproates/pharmacology; Animals; Brain Chemistry/drug effects; Drug Synergism; Isonicotinic Acids/pharmacology; Isoxazoles/pharmacology; Male; Motor Activity/drug effects; Muscimol/pharmacology; Nipecotic Acids/pharmacology; Olfactory Bulb/drug effects; Proline/analogs & derivatives; Rats; Rats, Inbred Strains; Synaptic Transmission/drug effects; Valproic Acid/pharmacology; Vigabatrin; gamma-Aminobutyric Acid/physiology;