Article date: 1986/8/4
PubMed ID: 3016441
Journal name: Life sciences (ISSN: 0024-3205)
In previous studies the involvement of nigrostriatal dopaminergic activity in ACTH(1-24)-induced grooming has been established. It was suggested that the dopaminergic modulation of ACTH(1-24)-induced excessive grooming is exerted through the striato-nigro-collicular pathway. To obtain further evidence it was investigated, whether local application of GABAergic agents into the colliculus superior modulates excessive grooming occurring after an intraventricular injection with ACTH(1-24). It appeared that intra-collicular picrotoxin (a GABAergic antagonist) suppressed ACTH-induced grooming, whereas muscimol (a GABAergic agonist) enhanced the grooming response. The picrotoxin-induced R(unning) F(it) B(ehavior), elicited from the colliculus superior was also seen after intraventricular administration of picrotoxin. A detailed comparison of this behavioral response seen after both routes of administration of picrotoxin suggests that intraventricularly injected picrotoxin may well induce the RFB via a direct effect on the colliculus superior. Lesions placed in the colliculus superior completely abolished picrotoxin-induced RFB, exploration and orientation behavior. Yet, these lesions did not reduce excessive grooming suggesting that although this region may be involved in the modulation of ACTH-induced grooming it is not the primary site of peptide action.
Author List: Spruijt B M, Ellenbroek B, Cools A R, Gispen W H
Publication Types: Journal Article
Substances mentioned in the article: GABA Antagonists; Picrotoxin; Cosyntropin; Muscimol; gamma-Aminobutyric Acid; Adrenocorticotropic Hormone;
Mesh terms: Adrenocorticotropic Hormone/analogs & derivatives; Animals; Behavior, Animal/drug effects; Cosyntropin/administration & dosage; GABA Antagonists; Grooming/drug effects; Injections, Intraventricular; Male; Muscimol/administration & dosage; Picrotoxin/administration & dosage; Rats; Rats, Inbred Strains; Superior Colliculi/drug effects; gamma-Aminobutyric Acid/physiology;