Sexual dimorphism in the response of the GABAergic system to estrogen administration.

Article date: 1986/12/1

PubMed ID: 3021905

Journal name: Journal of neurochemistry (ISSN: 0022-3042)


Administration of estradiol benzoate to gonadectomized female rats results in up-regulation of CNS gamma-aminobutyric acid (GABA) receptors. The increase of [3H]muscimol binding activity is observed in six of the seven brain areas examined. The same treatment, performed in castrated male or androgenized female rats, induced an increase of [3H]muscimol binding only in the striatum. Evidence is provided suggesting that the dimorphic sensitivity of GABA receptor is not correlated with the difference in spontaneous motor activity reported between male and female rats.

This document is available from: http://directlinks.cc/files/muscimol/3021905.pdf

Author List: Perez J, Zucchi I, Maggi A

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Estrogens; Receptors, GABA-A; Muscimol; Estradiol; gamma-Aminobutyric Acid;

Mesh terms: Animals; Brain/drug effects; Estradiol/pharmacology; Estrogens/pharmacology; Female; Male; Muscimol/metabolism; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Sex Characteristics; gamma-Aminobutyric Acid/metabolism;

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