Article date: 1986/9/9
PubMed ID: 3024997
Journal name: European journal of pharmacology (ISSN: 0014-2999)
Pretreatment of the guinea-pig ileum with capsaicin resulted consistently in depression of the neurogenic cholinergic contractions induced by the GABAA receptor agonists 3-aminopropane sulphonic acid (3-APS) and muscimol. Since capsaicin acts mainly by releasing and depleting substance P from its stores in intestinal nerves, it is likely that substance P plays a role in the response caused by GABAA-mimetic compounds, On the whole, our results suggest that excitatory responses to 3-APS and muscimol result from both direct and indirect activation of intrinsic intestinal cholinergic neurons innervating smooth muscle cells.
Author List: Tonini M, Onori L, Rizzi C A, De Ponti F, Perucca E, Budassi P, Crema A
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Receptors, GABA-A; Muscimol; Capsaicin; Bicuculline;
Mesh terms: Animals; Bicuculline/pharmacology; Capsaicin/pharmacology; Cholinergic Fibers/drug effects; Female; Guinea Pigs; Ileum/innervation; In Vitro Techniques; Male; Muscimol/pharmacology; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Receptors, GABA-A/drug effects;