3026521

[Regulation of 3H-dopamine release by presynaptic GABA and glutamate heteroreceptors in the synaptosomes of the rat nucleus accumbens].

Article date: 1987/1/1

PubMed ID: 3026521

Journal name: Biulleten' eksperimental'noi biologii i meditsiny (ISSN: 0365-9615)

ABSTRACT

The influence of GABA, muscimol, delta-aminolevulinic acid (DALA), baclofen and L-glutamate on K+-evoked release of 3H-dopamine (3H-DA) from the rat brain n. accumbens crude synaptosomal fraction was studied in superfusion experimental conditions. Both GABA-receptor agonists–GABA and muscimol (50 microM) depressed the 3H-DA release by bicuculline- and picrotoxin-sensitive manner. On the contrary, glutamate, DALA and baclofen led to the increase in 3H-DA efflux independently of the presence of GABA-receptor antagonists. While the action of glutamate was antagonized by glutamate-receptor blocker–glutamic acid diethyl ester (GDEE), the effects of DALA and baclofen were suppressed upon adding to superfusion medium of GABA uptake inhibitors (nipecotic acid and 2,4-diaminobutyric acid) but not GDEE. The data obtained demonstrate that 3-H-DA secretion from n. accumbens is inhibited by GABA- and stimulated by glutamate-heteroreceptors. At the same time the mechanism of interaction between baclofen, DALA and GABA-uptake blockers effects with 3H-DA release needs special investigations.

Author List: Kovalev G I, Hetey L

Publication Types: Comparative Study; English Abstract; Journal Article

Substances mentioned in the article: Glutamates; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Tritium; Dopamine;

Mesh terms: Animals; Dopamine/metabolism; Glutamates/metabolism; Male; Nucleus Accumbens/drug effects; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Receptors, Glutamate; Receptors, Neurotransmitter/drug effects; Septal Nuclei/metabolism; Synaptosomes/drug effects; Tritium;

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