Article date: 1987/3/3
PubMed ID: 3032348
Journal name: Brain research (ISSN: 0006-8993)
The role of the substantia nigra in seizure development was investigated using a chronic model of partial onset generalized seizure induced by low frequency cortical stimulation. Unilateral intranigral micro-injection of muscimol, a GABA receptor agonist, was found to facilitate partial onset seizure development, but did not affect developed seizures. This finding suggested that a non-dopaminergic, presumably GABAergic, mechanism was involved since the facilitatory effect of intranigral muscimol was not modified by haloperidol pretreatment.
Author List: Ono K, Wada J A
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Muscimol; gamma-Aminobutyric Acid; Dopamine;
Mesh terms: Animals; Dopamine/physiology; Epilepsies, Partial/physiopathology; Male; Microinjections; Motor Cortex/physiopathology; Muscimol; Rats; Rats, Inbred Strains; Substantia Nigra/physiopathology; Synaptic Transmission; Thalamic Nuclei/physiopathology; gamma-Aminobutyric Acid/physiology;