Facilitation of premotor cortical seizure development by intranigral muscimol.

Article date: 1987/3/3

PubMed ID: 3032348

Journal name: Brain research (ISSN: 0006-8993)


The role of the substantia nigra in seizure development was investigated using a chronic model of partial onset generalized seizure induced by low frequency cortical stimulation. Unilateral intranigral micro-injection of muscimol, a GABA receptor agonist, was found to facilitate partial onset seizure development, but did not affect developed seizures. This finding suggested that a non-dopaminergic, presumably GABAergic, mechanism was involved since the facilitatory effect of intranigral muscimol was not modified by haloperidol pretreatment.

This document is available from: http://directlinks.cc/files/muscimol/3032348.pdf

Author List: Ono K, Wada J A

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Muscimol; gamma-Aminobutyric Acid; Dopamine;

Mesh terms: Animals; Dopamine/physiology; Epilepsies, Partial/physiopathology; Male; Microinjections; Motor Cortex/physiopathology; Muscimol; Rats; Rats, Inbred Strains; Substantia Nigra/physiopathology; Synaptic Transmission; Thalamic Nuclei/physiopathology; gamma-Aminobutyric Acid/physiology;

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