Neurotransmission in the pedunculopontine nucleus and pilocarpine-induced motor limbic seizures in rats.

Article date: 1987/2/24

PubMed ID: 3033555

Journal name: Neuroscience letters (ISSN: 0304-3940)


Systemic injection of the cholinergic agonist, pilocarpine (380 mg/kg, i.p.) initiates a sequence of events leading to motor limbic seizure activity. Focal injection of the excitatory amino acid antagonist, 2-amino-7-phosphonoheptanoic acid (50 pmol-1 nmol) into the pedunculopontine nucleus (PPN), prior to pilocarpine injection, results in a powerful anticonvulsant action. The GABA agonist, muscimol (25-50 pmol) also afforded protection against pilocarpine-evoked convulsions when injected focally into the PPN. The results suggest that an overall inhibition of PPN output neurons is required for anticonvulsant action.

This document is available from: http://directlinks.cc/files/muscimol/3033555.pdf

Author List: Patel S, Millan M H, Meldrum B S

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Amino Acids; Pilocarpine; Muscimol; 2-Amino-5-phosphonovalerate; 2-amino-7-phosphonoheptanoic acid;

Mesh terms: 2-Amino-5-phosphonovalerate/analogs & derivatives; Amino Acids/pharmacology; Animals; Basal Ganglia/physiopathology; Cerebellum/physiopathology; Limbic System/physiopathology; Male; Muscimol/pharmacology; Pilocarpine/pharmacology; Pons/physiopathology; Rats; Rats, Inbred Strains; Seizures/physiopathology; Synaptic Transmission/drug effects;

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