Article date: 1987/2/24
PubMed ID: 3033555
Journal name: Neuroscience letters (ISSN: 0304-3940)
Systemic injection of the cholinergic agonist, pilocarpine (380 mg/kg, i.p.) initiates a sequence of events leading to motor limbic seizure activity. Focal injection of the excitatory amino acid antagonist, 2-amino-7-phosphonoheptanoic acid (50 pmol-1 nmol) into the pedunculopontine nucleus (PPN), prior to pilocarpine injection, results in a powerful anticonvulsant action. The GABA agonist, muscimol (25-50 pmol) also afforded protection against pilocarpine-evoked convulsions when injected focally into the PPN. The results suggest that an overall inhibition of PPN output neurons is required for anticonvulsant action.
Author List: Patel S, Millan M H, Meldrum B S
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Amino Acids; Pilocarpine; Muscimol; 2-Amino-5-phosphonovalerate; 2-amino-7-phosphonoheptanoic acid;
Mesh terms: 2-Amino-5-phosphonovalerate/analogs & derivatives; Amino Acids/pharmacology; Animals; Basal Ganglia/physiopathology; Cerebellum/physiopathology; Limbic System/physiopathology; Male; Muscimol/pharmacology; Pilocarpine/pharmacology; Pons/physiopathology; Rats; Rats, Inbred Strains; Seizures/physiopathology; Synaptic Transmission/drug effects;