Article date: 1987/3/31
PubMed ID: 3034637
Journal name: European journal of pharmacology (ISSN: 0014-2999)
The possibility of a functional interdependence between central GABAA receptors and beta 2-adrenoceptors has been investigated using the ability of both types of agonist to potentiate the tic (head-twitch) response to 5-methoxy-N,N-dimethyltryptamine in the mouse. At a dose which selectively antagonised beta 1- but not beta 2-adrenoceptors, ICI 118,551 abolished the effects of single doses of muscimol, diazepam and pentobarbitone. Conversely, bicuculline abolished the potentiation caused by the beta 2-adrenoceptor agonist procaterol. Thus there is preliminary evidence that these two receptor types do show mutual interdependence.
Author List: Singh L, Handley S L
Publication Types: Journal Article
Substances mentioned in the article: Methoxydimethyltryptamines; Propanolamines; Receptors, Adrenergic, beta; Receptors, GABA-A; ICI 118551; Bicuculline;
Mesh terms: Animals; Behavior, Animal/drug effects; Bicuculline/pharmacology; Male; Methoxydimethyltryptamines/pharmacology; Mice; Propanolamines/pharmacology; Receptors, Adrenergic, beta/physiology; Receptors, GABA-A/physiology;