35117

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35117 [2018/11/22 21:16] (current)
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 +====== Improvement in tardive dyskinesia after muscimol therapy.======
 +
 +** Article date:** 1979/5/1
 +~~META:date created = 1979-05-01~~
 +
 +** PubMed ID: 35117 **
 +
 +** Journal name: Archives of general psychiatry (ISSN: 0003-990X) **
 +
 +** ABSTRACT **
 +
 +Muscimol, thought to be a agonist of gamma-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia. At oral dose levels from 5 to 9 mg, involuntary movements were consistently attenuated, usually in the absence of sedation. These results support the view that pharmacologic attempts to stimulate GABA-mediated synaptic transmission may afford symptomatic relief to patients with tardive dyskinesia.
 +
 +===== ===== 
 +
 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​35117.pdf}}
 +
 +Author List: Tamminga C A, Crayton J W, Chase T N
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Antipsychotic Agents; Oxazoles; Receptors, Dopamine; Muscimol; gamma-Aminobutyric Acid; Dopamine; ​
 +
 +Mesh terms: Adult; Aged; Antipsychotic Agents/​adverse effects; Dopamine/​physiology;​ Drug Evaluation; Dyskinesia, Drug-Induced/​drug therapy; Extrapyramidal Tracts/drug effects; Female; Humans; Male; Middle Aged; Muscimol/​pharmacology;​ Oxazoles/​therapeutic use; Receptors, Dopamine/​drug effects; Schizophrenia/​drug therapy; Stimulation,​ Chemical; Synaptic Transmission/​drug effects; gamma-Aminobutyric Acid/​pharmacology; ​
 +
 +{{tag> gamma-Aminobutyric_Acid Receptors,​_Dopamine Muscimol Oxazoles Dopamine Antipsychotic_Agents }}
 +
 +{{keywords>​ gamma-Aminobutyric Acid, Receptors, Dopamine, Muscimol, Oxazoles, Dopamine, Antipsychotic Agents}}
 +
  
35117.txt · Last modified: 2018/11/22 21:16 (external edit)