Sodium bromide and sodium valproate: effective suppressants of ethanol withdrawal reactions in mice.

Article date: 1979/2/1

PubMed ID: 368313

Journal name: The Journal of pharmacology and experimental therapeutics (ISSN: 0022-3565)


Mice were made physically dependent on ethanol by a 3-day alcohol inhalation regimen, using pyrazole to stabilize blood ethanol concentrations. After withdrawal, convulsions elicited by handling were scored repeatedly for 30 hr as a measure of central nervous system hyperexcitability. Administration of sodium bromide, 0.2 to 2.0 g/kg i.p., suppressed the convulsions in a dose-related fashion. Bromide was effective at subsedative doses. However, bromide increased the postwithdrawal mortality. Bromide may act at chloride channels, as gamma-aminobutyric acid does. Valproate and its amide temporarily suppressed the withdrawal reaction at doses that caused some sedation. Muscimol and beta-alanine had no effect.

Author List: Goldstein D B

Publication Types: Journal Article

Substances mentioned in the article: Bromides; Valproic Acid;

Mesh terms: Alcoholism/physiopathology; Animals; Bromides/pharmacology; Dose-Response Relationship, Drug; Humans; Male; Mice; Postural Balance/drug effects; Seizures/physiopathology; Substance Withdrawal Syndrome/physiopathology; Valproic Acid/pharmacology;

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