368313

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368313 [2018/11/20 14:26] (current)
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 +====== Sodium bromide and sodium valproate: effective suppressants of ethanol withdrawal reactions in mice.======
 +
 +** Article date:** 1979/2/1
 +~~META:date created = 1979-02-01~~
 +
 +** PubMed ID: 368313 **
 +
 +** Journal name: The Journal of pharmacology and experimental therapeutics (ISSN: 0022-3565) **
 +
 +** ABSTRACT **
 +
 +Mice were made physically dependent on ethanol by a 3-day alcohol inhalation regimen, using pyrazole to stabilize blood ethanol concentrations. After withdrawal, convulsions elicited by handling were scored repeatedly for 30 hr as a measure of central nervous system hyperexcitability. Administration of sodium bromide, 0.2 to 2.0 g/kg i.p., suppressed the convulsions in a dose-related fashion. Bromide was effective at subsedative doses. However, bromide increased the postwithdrawal mortality. Bromide may act at chloride channels, as gamma-aminobutyric acid does. Valproate and its amide temporarily suppressed the withdrawal reaction at doses that caused some sedation. Muscimol and beta-alanine had no effect.
 +
 +===== ===== 
 +
 +Author List: Goldstein D B
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Bromides; Valproic Acid; 
 +
 +Mesh terms: Alcoholism/​physiopathology;​ Animals; Bromides/​pharmacology;​ Dose-Response Relationship,​ Drug; Humans; Male; Mice; Postural Balance/​drug effects; Seizures/​physiopathology;​ Substance Withdrawal Syndrome/​physiopathology;​ Valproic Acid/​pharmacology; ​
 +
 +{{tag> Bromides Valproic_Acid }}
 +
 +{{keywords>​ Bromides, Valproic Acid}}
 +
  
368313.txt ยท Last modified: 2018/11/20 14:26 (external edit)