388131

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388131 [2018/11/20 14:25] (current)
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 +====== Effect of latent iron deficiency on gaba and glutamate neuroreceptors in rat brain.======
 +
 +** Article date:** 2002/7/1
 +~~META:date created = 2002-07-01~~
 +
 +** PubMed ID: 388131 **
 +
 +** Journal name: Indian journal of clinical biochemistry : IJCB (ISSN: 0970-1915) **
 +
 +** DOI: 10.1007/​BF02867966 **
 +
 +** ABSTRACT **
 +
 +Eight weeks of latent iron deficiency in weaned female rats of Sprague Dawley strain maintained on experimental low-iron diet (18-20 mg/Kg) did not significantly change the gross body weight and tissue weights of brain and liver. Packed cell volume (PCV) and hemoglobin concentration remained unaltered. However, non-heme iron content in liver and brain decreased significantly (P<​0.001). The activities of glutamate dehydrogenase,​ glutamic acid decarboxylase,​ and GABA-transaminase (GABA-T) in brain decreased by 15%, 11.4% and 25.7% respectively. However, this decrease was not statistically significant. Binding of(3)H Muscimol at pH 7.5 and 1 mg protein/​assay increased by 143% (P<​0.001) in synaptic vesicular membranes from iron-deficient rats as compared to the controls.(3)H glutamate binding to the synaptic vesicles was also carried out under similar condition. However, the L-glutamate binding was reduced by 63% in the vesicular membranes of iron deficient animals. These studies in dicate that iron plays an important functional role in both excitatory and inhibitory neurotransmitter receptors.
 +
 +===== ===== 
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 +Author List: Mittal Rama Devi, Pandey Amita, Mittal Balraj, Agarwal Kailash Nath
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 +Publication Types: Journal Article
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 +Substances mentioned in the article: ​
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 +Mesh terms: ​
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 +Citations: ​  - //​[[1688846]]//​
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 +{{tag> brain_synaptic_vesicles GABA/​glutamate_metabolism [3H]_Muscimol 3H_glutamate Neurotransmitters Neurotransmitter_receptors }}
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 +{{keywords>​ brain synaptic vesicles, GABA/​glutamate metabolism, [3H] Muscimol, 3H glutamate, Neurotransmitters,​ Neurotransmitter receptors}}
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388131.txt ยท Last modified: 2018/11/20 14:25 (external edit)