Valproate enhances GABA-A mediated inhibition of locus coeruleus neurones in vitro.

Article date: 1988/12/1

PubMed ID: 39147

Journal name: Naunyn-Schmiedeberg's archives of pharmacology (ISSN: 0028-1298)


It has previously been claimed that the anticonvulsant valproate acts by augmenting GABA-ergic transmission, however, the data supporting this claim is controversial. Here we demonstrate that valproate strongly and reversibly potentiates the depressant effects of the GABA-A receptor agonist muscimol on locus coeruleus neurones recorded extracellularly from a midpontine slice preparation of the rat. The depressant effect of muscimol (2 microM) is augmented by bath applied valproate at concentrations of 50 microM, 100 microM and 1 mM. The effect of GABA is also potentiated by valproate. The potentiating effect is selective since the cell inhibition elicited by the GABA-B receptor agonist baclofen is not affected. Valproate on its own had no effect on the firing frequency.

Author List: Olpe H R, Steinmann M W, Pozza M F, Brugger F, Schmutz M

Publication Types: Journal Article

Substances mentioned in the article: Receptors, GABA-A; Muscimol; gamma-Aminobutyric Acid; Valproic Acid;

Mesh terms: Animals; In Vitro Techniques; Locus Coeruleus/cytology; Male; Muscimol/pharmacology; Neurons/drug effects; Rats; Rats, Inbred Strains; Receptors, GABA-A/metabolism; Valproic Acid/pharmacology; gamma-Aminobutyric Acid/physiology;

Citations: - 2830939

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