400990

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400990 [2018/11/22 21:16] (current)
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 +====== Effects of GABA-mimetic agents on the cat spinal cord.======
 +
 +** Article date:** 1979/1/1
 +~~META:date created = 1979-01-01~~
 +
 +** PubMed ID: 400990 **
 +
 +** Journal name: Progress in neuro-psychopharmacology (ISSN: 0364-7722) **
 +
 +** ABSTRACT **
 +
 +Muscimol, ibotenic acid, isoguvacine,​ 4,​5,​6,​7-tetrahydroisoxazolo [5,​4-c]pyridin-3-ol (THIP) and gamma-aminobutyric acid (GABA) injected intravenously exerted the following dose-dependent effects on the lumbosacral spinal cord of spinal cats: 1. The excitability of primary afferents and the amplitude of dorsal root reflexes were enhanced; segmental monosynaptic ventral root reflexes and dorsal root potentials as well as the spontaneous gamma-fibre activity and, to a smaller extent, the excitability of motoneurons and polysynaptic reflexes, were depressed. 2. Muscimol was the most potent compound (0.3-1 mg/kg produced significant effects), followed by ibotenic acid (3-10 mg/kg), isoguvacine and THIP (10-30 mg/kg) and GABA (100 mg/kg). 3. Most effects were reversibly antagonized by bicuculline,​ but not by strychnine, indicating that they were due to a specific interaction with GABA-receptors. 4. These results suggest that the systemic injection of GABA-mimetic agents affects spinal cord activities by actions related to GABA-receptors located on primary afferent endings, intrinsic spinal neurons, and motoneurons.
 +
 +===== ===== 
 +
 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​400990.pdf}}
 +
 +Author List: Polc P
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: GABA Antagonists;​ Isonicotinic Acids; Isoxazoles; Ibotenic Acid; Muscimol; gamma-Aminobutyric Acid; gaboxadol; Bicuculline;​ isoguvacine; ​
 +
 +Mesh terms: Animals; Bicuculline/​pharmacology;​ Cats; Drug Interactions;​ GABA Antagonists;​ Ganglia, Spinal/​physiology;​ Ibotenic Acid/​pharmacology;​ Isonicotinic Acids/​pharmacology;​ Isoxazoles/​pharmacology;​ Male; Muscimol/​pharmacology;​ Neurons, Afferent/​physiology;​ Spinal Cord/drug effects; gamma-Aminobutyric Acid/​physiology; ​
 +
 +{{tag> Bicuculline GABA_Antagonists Isoxazoles Isonicotinic_Acids gamma-Aminobutyric_Acid isoguvacine Muscimol gaboxadol Ibotenic_Acid }}
 +
 +{{keywords>​ Bicuculline,​ GABA Antagonists,​ Isoxazoles, Isonicotinic Acids, gamma-Aminobutyric Acid, isoguvacine,​ Muscimol, gaboxadol, Ibotenic Acid}}
 +
  
400990.txt · Last modified: 2018/11/22 21:16 (external edit)