A methodological weakness in the use of neuroleptic antagonism as a sole criterion for DAergic mediation of drug-induced behavioural effects.

Article date: 1979/10/1

PubMed ID: 41722

Journal name: European journal of pharmacology (ISSN: 0014-2999)


Contralateral rotational behavior following unilateral injections of the GABA agonist muscimol (100 ng) or the GABA analogue baclofen (1 microgram) into the zona reticulata of the rat substantia nigra was moderately attenuated by pretreatment with haloperidol (0.4 mg/kg i.p.), but not by destruction of ipsilateral dopamine (DA) neurons induced with 6-hydroxydopamine. Antagonism by neuroleptics can erroneously indicate DAergic mechanisms in the behavioural effects of drugs if used as a sole criterion.

This document is available from: http://directlinks.cc/files/muscimol/41722.pdf

Author List: Waddington J L

Publication Types: Journal Article

Substances mentioned in the article: Antipsychotic Agents; Hydroxydopamines; Muscimol; Baclofen; Haloperidol; Dopamine;

Mesh terms: Animals; Antipsychotic Agents/antagonists & inhibitors; Baclofen/pharmacology; Behavior, Animal/drug effects; Dopamine/physiology; Haloperidol/pharmacology; Hydroxydopamines/pharmacology; Injections; Male; Muscimol/administration & dosage; Rats; Research Design; Substantia Nigra;

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