465686

[Role of the GABA-ergic systems of the brain in manifesting the activating effect of diazepam].

Article date: 1979/6/1

PubMed ID: 465686

Journal name: Biulleten' eksperimental'noi biologii i meditsiny (ISSN: 0365-9615)

ABSTRACT

It was shown in experiments on rats that the selective blocker of GABA receptors bicuculline (2 mg/kg) does not decrease the activating effect of diazepam as to the reaction of self-stimulation. The GABA-mimetic muscimol (0.5 and 1 mg/kg) had no effect on self-stimulation rate, while in the dose of 2 mg/kg causing behavioral changes produced a powerful decrease in it (by 93.3%). During the combined administration of diazepam and muscimol (1 mg/kg and 0.5 mg/kg, respectively) no potentiation of diazepam effect was observed. It is suggested that diazepam-induced facilitation of the reaction of self-stimulation is not due to the alteration in the activity of GABA-ergic processes.

Author List: Val'dman A V, Marusov I V

Publication Types: English Abstract; Journal Article

Substances mentioned in the article: Receptors, Drug; Muscimol; gamma-Aminobutyric Acid; Diazepam; Bicuculline;

Mesh terms: Animals; Bicuculline/pharmacology; Brain/drug effects; Diazepam/pharmacology; Dose-Response Relationship, Drug; Motor Activity/drug effects; Muscimol/pharmacology; Rats; Receptors, Drug/drug effects; Self Stimulation/drug effects; gamma-Aminobutyric Acid/physiology;

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