465686

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465686 [2018/11/20 14:26] (current)
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 +====== [Role of the GABA-ergic systems of the brain in manifesting the activating effect of diazepam].======
 +
 +** Article date:** 1979/6/1
 +~~META:date created = 1979-06-01~~
 +
 +** PubMed ID: 465686 **
 +
 +** Journal name: Biulleten'​ eksperimental'​noi biologii i meditsiny (ISSN: 0365-9615) **
 +
 +** ABSTRACT **
 +
 +It was shown in experiments on rats that the selective blocker of GABA receptors bicuculline (2 mg/kg) does not decrease the activating effect of diazepam as to the reaction of self-stimulation. The GABA-mimetic muscimol (0.5 and 1 mg/kg) had no effect on self-stimulation rate, while in the dose of 2 mg/kg causing behavioral changes produced a powerful decrease in it (by 93.3%). During the combined administration of diazepam and muscimol (1 mg/kg and 0.5 mg/kg, respectively) no potentiation of diazepam effect was observed. It is suggested that diazepam-induced facilitation of the reaction of self-stimulation is not due to the alteration in the activity of GABA-ergic processes.
 +
 +===== ===== 
 +
 +Author List: Val'​dman A V, Marusov I V
 +
 +Publication Types: English Abstract; Journal Article
 +
 +Substances mentioned in the article: Receptors, Drug; Muscimol; gamma-Aminobutyric Acid; Diazepam; Bicuculline; ​
 +
 +Mesh terms: Animals; Bicuculline/​pharmacology;​ Brain/drug effects; Diazepam/​pharmacology;​ Dose-Response Relationship,​ Drug; Motor Activity/​drug effects; Muscimol/​pharmacology;​ Rats; Receptors, Drug/drug effects; Self Stimulation/​drug effects; gamma-Aminobutyric Acid/​physiology; ​
 +
 +{{tag> Bicuculline Diazepam Receptors,​_Drug gamma-Aminobutyric_Acid Muscimol }}
 +
 +{{keywords>​ Bicuculline,​ Diazepam, Receptors, Drug, gamma-Aminobutyric Acid, Muscimol}}
 +
  
465686.txt · Last modified: 2018/11/20 14:26 (external edit)