Article date: 1988/2/1
PubMed ID: 490160
Journal name: British journal of pharmacology (ISSN: 0007-1188)
1. gamma-Aminobutyric acid (GABA) inhibited the antidiuretic response and the increased urinary excretion of vasopressin produced by carbachol when both drugs were injected into a lateral cerebral ventricle (i.c.v.) in the water-loaded rat under ethanol anaesthesia. 2. The inhibitory effect of GABA was mimicked by muscimol and 3-amino-1-propane sulphonic acid (3-APS) and blocked by bicuculline. 3. GABA injected i.v. or into the cisterna magna (i.cist.) did not inhibit the release of vasopressin by carbachol injected i.c.v. 4. The results suggest a role for GABA as a putative inhibitory transmitter in the hypothalamo-neurohypophysial system, acting directly on the supraoptic or paraventricular nuclei in the anterior hypothalamus.
Author List: Chowdrey H S, Bisset G W
Publication Types: Journal Article
Substances mentioned in the article: Vasopressins; gamma-Aminobutyric Acid; Carbachol;
Mesh terms: Animals; Blood Pressure/drug effects; Carbachol/antagonists & inhibitors; Diuresis/drug effects; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Vasopressins/urine; gamma-Aminobutyric Acid/administration & dosage;