490160

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490160 [2018/11/20 14:26] (current)
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 +====== Central inhibition by gamma-aminobutyric acid of the release of vasopressin by carbachol in the rat.======
 +
 +** Article date:** 1988/2/1
 +~~META:date created = 1988-02-01~~
 +
 +** PubMed ID: 490160 **
 +
 +** Journal name: British journal of pharmacology (ISSN: 0007-1188) **
 +
 +** ABSTRACT **
 +
 +1. gamma-Aminobutyric acid (GABA) inhibited the antidiuretic response and the increased urinary excretion of vasopressin produced by carbachol when both drugs were injected into a lateral cerebral ventricle (i.c.v.) in the water-loaded rat under ethanol anaesthesia. 2. The inhibitory effect of GABA was mimicked by muscimol and 3-amino-1-propane sulphonic acid (3-APS) and blocked by bicuculline. 3. GABA injected i.v. or into the cisterna magna (i.cist.) did not inhibit the release of vasopressin by carbachol injected i.c.v. 4. The results suggest a role for GABA as a putative inhibitory transmitter in the hypothalamo-neurohypophysial system, acting directly on the supraoptic or paraventricular nuclei in the anterior hypothalamus.
 +
 +===== ===== 
 +
 +Author List: Chowdrey H S, Bisset G W
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Vasopressins;​ gamma-Aminobutyric Acid; Carbachol; ​
 +
 +Mesh terms: Animals; Blood Pressure/​drug effects; Carbachol/​antagonists & inhibitors; Diuresis/​drug effects; Injections, Intravenous;​ Injections, Intraventricular;​ Male; Rats; Rats, Inbred Strains; Vasopressins/​urine;​ gamma-Aminobutyric Acid/​administration & dosage; ​
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 +Citations: ​  - //​[[476481]]//​
 +  - //​[[460710]]//​
 +  - //​[[7192856]]//​
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 +  - //​[[6634883]]//​
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 +  - //​[[11370234]]//​
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 +  - //​[[5104566]]//​
 +  - //​[[4480090]]//​
 +  - //​[[1236754]]//​
 +  - //​[[885114]]//​
 +  - //​[[302137]]//​
 +  - //​[[620101]]//​
 +  - //​[[698812]]//​
 +  - //​[[436724]]//​
 +  - //​[[458717]]//​
 +  - //​[[490160]]//​
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 +{{tag> gamma-Aminobutyric_Acid Vasopressins Carbachol }}
 +
 +{{keywords>​ gamma-Aminobutyric Acid, Vasopressins,​ Carbachol}}
 +
  
490160.txt · Last modified: 2018/11/20 14:26 (external edit)