510380

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510380 [2018/11/22 21:16] (current)
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 +====== THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding.======
 +
 +** Article date:** 1979/10/15
 +~~META:date created = 1979-10-15~~
 +
 +** PubMed ID: 510380 **
 +
 +** Journal name: European journal of pharmacology (ISSN: 0014-2999) **
 +
 +** ABSTRACT **
 +
 +The effects of THIP and isoguvacine on 3H-flunitrazepam binding to washed membranes prepared from the cerebral cortex of adult rats have been examined. THIP, which has only minimal stimulatory effects on benzodiazepine (BZ) receptor binding, has been found to inhibit the stimulation induced by small concentrations (2 microM) of exogenous GABA. While isoguvacine stimulates BZ receptor binding, although to a smaller extent than GABA, it also antagonizes the stimulation of BZ receptor binding induced by GABA. Thus THIP and isoguvacine exhibit the properties of a partial agonist of GABA-stimulated BZ receptor binding.
 +
 +===== ===== 
 +
 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​510380.pdf}}
 +
 +Author List: Karobath M, Lippitsch M
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Isonicotinic Acids; Isoxazoles; Oxazoles; Receptors, Drug; Benzodiazepines;​ Muscimol; gamma-Aminobutyric Acid; Flunitrazepam; ​
 +
 +Mesh terms: Animals; Benzodiazepines/​metabolism;​ Cerebral Cortex/​metabolism;​ Drug Synergism; Flunitrazepam/​metabolism;​ In Vitro Techniques; Isonicotinic Acids/​pharmacology;​ Isoxazoles/​pharmacology;​ Muscimol/​pharmacology;​ Oxazoles/​pharmacology;​ Rats; Receptors, Drug/drug effects; gamma-Aminobutyric Acid/​pharmacology; ​
 +
 +{{tag> Flunitrazepam Receptors,​_Drug Isonicotinic_Acids gamma-Aminobutyric_Acid Benzodiazepines Muscimol Oxazoles Isoxazoles }}
 +
 +{{keywords>​ Flunitrazepam,​ Receptors, Drug, Isonicotinic Acids, gamma-Aminobutyric Acid, Benzodiazepines,​ Muscimol, Oxazoles, Isoxazoles}}
 +
  
510380.txt · Last modified: 2018/11/22 21:16 (external edit)