Article date: 1979/10/26
PubMed ID: 510396
Journal name: European journal of pharmacology (ISSN: 0014-2999)
The effects of muscimol on rabbit hippocampal pyramidal cell firing were studied and compared after iontophoretic, topical, and intravenous administration of the drug. All modes of application resulted in a bicuculline-sensitive, strychnine-insensitive, depression of the monosynaptically activated population spike evoked by micro-stimulation of the contralateral hippocampal field. These findings indicate that systemically administered muscimol selectively activates hippocampal GABA receptors suggesting that this compound may be useful for studying limbic system physiology.
Author List: Defrance J, Stanley J, Marchand J, Enna S J
Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Oxazoles; Muscimol; Strychnine; Bicuculline;
Mesh terms: Action Potentials/drug effects; Animals; Bicuculline/pharmacology; Electric Stimulation; Hippocampus/drug effects; Humans; In Vitro Techniques; Male; Muscimol/pharmacology; Oxazoles/pharmacology; Pyramidal Tracts/drug effects; Rabbits; Strychnine/pharmacology; Synapses/drug effects; Time Factors;