510396

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510396 [2018/11/22 21:16] (current)
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 +====== The effect of muscimol on hippocampal pyramidal cells.======
 +
 +** Article date:** 1979/10/26
 +~~META:date created = 1979-10-26~~
 +
 +** PubMed ID: 510396 **
 +
 +** Journal name: European journal of pharmacology (ISSN: 0014-2999) **
 +
 +** ABSTRACT **
 +
 +The effects of muscimol on rabbit hippocampal pyramidal cell firing were studied and compared after iontophoretic,​ topical, and intravenous administration of the drug. All modes of application resulted in a bicuculline-sensitive,​ strychnine-insensitive,​ depression of the monosynaptically activated population spike evoked by micro-stimulation of the contralateral hippocampal field. These findings indicate that systemically administered muscimol selectively activates hippocampal GABA receptors suggesting that this compound may be useful for studying limbic system physiology.
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 +===== ===== 
 +
 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​510396.pdf}}
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 +Author List: Defrance J, Stanley J, Marchand J, Enna S J
 +
 +Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
 +
 +Substances mentioned in the article: Oxazoles; Muscimol; Strychnine; Bicuculline; ​
 +
 +Mesh terms: Action Potentials/​drug effects; Animals; Bicuculline/​pharmacology;​ Electric Stimulation;​ Hippocampus/​drug effects; Humans; In Vitro Techniques; Male; Muscimol/​pharmacology;​ Oxazoles/​pharmacology;​ Pyramidal Tracts/drug effects; Rabbits; Strychnine/​pharmacology;​ Synapses/​drug effects; Time Factors; ​
 +
 +{{tag> Oxazoles Strychnine Bicuculline Muscimol }}
 +
 +{{keywords>​ Oxazoles, Strychnine, Bicuculline,​ Muscimol}}
 +
  
510396.txt · Last modified: 2018/11/22 21:16 (external edit)